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Raptor drugs command huge potential

Thirst plagued her childhood. When other kids bolted to the playground at recess, Stephanie Trudell sneaked into the bathroom to guzzle water. It brought brief respite. Her unslaked thirst roared back. "I was always thirsty," she said, "always thirsty."

As with many of nearly 7,000 rare diseases caused by genetic flaws, Trudell’s symptoms showed up soon after birth. When she was nine months old, doctors diagnosed incurable nephropathic (infantile) cystinosis. The disease afflicts 500 patients in the United States and 2,000 worldwide, primarily children, and provides a potentially $300 million market for a drug treatment launched in 2013 by Novato based Raptor Pharmaceutical Corp. The company, which sold about $70 million of its cystinosis drug Procysbi in the first year after FDA approval, has 82 employees in Novato and 120 worldwide.

Now 35, Trudell flew from her home in Omaha, Neb., to visit Raptor for Rare Diseases Day at the end of February. Julie Anne Smith, who took over Raptor’s reins as CEO and president in January, celebrated Trudell and other patients the company’s raison d’tre.

Beyond thirst, cystinosis causes another unpleasant symptom, Trudell said: eye crystals, which cause irritation and blur, especially in bright sun. "It looks like shattered glass," Trudell said. "Sunlight made my eyes burn. I can’t see when it’s bright out, when it’s night." She has bifocals "and it’s still hard," she said.

Cystinosis caused by errant CTNS genes on the 17p13 chromosome appears when amino acid cystine goes into cells then cannot escape. Cells overloaded with cystine crystallize and die usually cells in the kidneys, liver, eyes, muscles, white blood cells and central nervous system. Cystinosis also delays a child’s growth.

Cystinosis was treatable when Trudell was a child: the drug Cystagon, or cysteamine bitartrate, breaks down cystine, has to be taken every six hours and causes severe nausea as well as awful body odor like rotten eggs. Cystagon, initially a liquid then in capsule form, costs about $8,000 a year, but its side effects prompt many patients to balk. "Cystagon is terrible. It made me sick to my stomach," Trudell said.

"I used to stash and hide my meds. It was so gross," she said. "I would put it in a baggie under my mattress, in my dresser drawer." Her kidneys failed at age 14, leading to a transplant from her
cheap ray bans mother in 1993, hemodialysis then a second kidney transplant in 2006 after she stopped taking Cystagon. "Dialysis really sucks," she said. "I had a poor attitude. I was living, but I wasn’t really living."

Trudell started taking Raptor’s Procysbi in November 2014. "I can take it," she said. "I’m not sick. It changed my life."

Raptor scientists found an ingenious way to reformulate cysteamine bitartrate molecules and deliver them with delayed release directly to the intestine, bypassing the stomach and curbing nausea. "What was novel," CEO Smith said, "was recognition that if you delivered it to
replica ray ban sunglasses the duodenum (small intestine), bioavailability was improved. The specific way we coated the microbeads gave us continuous levels of therapeutic" cysteamine bitartrate despite lower quantities of the drug.

Procysbi, which costs $250,000 a year, radically changed Trudell’s life and caused few side effects. "Oh my gosh. It makes me feel better," she said, "makes me want to get up out of bed." Trudell lives on Social Security disability income; medical bills are covered by government programs. Persistent thirst remains. The drug reduced crystals in her eyes.

This year holds big potential for Raptor beyond Procysbi, according to Smith, who assumed leadership of Raptor from co founder Christopher Starr. The company’s name derived originally from work on receptor associated proteins (RAP), but the focus shifted.

"He is one of the unsung biotech pioneers," Smith said. Starr co founded BioMarin, located in San Rafael, and was the primary founder of Raptor. "He is a discovery and development guy. Once the business turns commercial," he hankers for more science, she said. Starr still consults with Raptor on science and sits on its board.

Procysbi provides "really nice momentum on our revenue," Smith said, and could rise to $90 million in 2015. On Feb. 26, the company reported fourth quarter 2014 revenue of $17.3 million. Annual revenue was nearly $70 million, up from $17 million in 2013. The company, which went public in 2003, had net losses of $52.5 million for 2014, and accumulated deficit of $258 million.

A small fraction of Procysbi revenue comes from sales in Europe. "People are afraid of Europe," she said. "It’s tougher," and difficult to govern business from afar.

Raptor could ultimately reap annual revenue of nearly $250 million from sales of Procysbi, she said. "The range is $150 million to $300 million if you make reasonable assumptions about product market penetration," she said. Patients in many countries could not afford the drug. market exclusivity for cystinosis for 7.5 years under the Orphan Drug Act of 1983 and the Rare Diseases Act of 2002. "The Orphan Drug Act was essential to provide incentives to companies to develop and invest in" drugs for rare diseases, Smith said.

A Raptor drug called RP103 also a formulation of cysteamine bitartrate holds promise in treating several diseases. "What we’re excited about is RP103′s potential" in these other therapeutic areas that have much larger markets, Smith said.

Raptor is conducting RP103 clinical trials with Huntington’s Disease, a neural degeneration, with a potential market of
replica ray bans about 70,000 patients in the United States and Europe, and 100,000 worldwide.

In conjunction with the National Institutes of Health, Raptor has phase two clinical trials of RP103 for treating pediatric non alcoholic fatty liver disease, which can lead to liver failure. Nearly a third of Americans, roughly 100 million people, have the disease, which affects some 15 percent of American children. Non alcoholic steatohepatitis (NASH), an aggressive form of non alcoholic fatty liver disease, causes degeneration of fat in the liver. Raptor clinical trials focus on children with NASH. Many other biotech companies are pursuing treatment for adults with NASH.

"NASH is occurring in people at younger and younger ages," Smith said. "This is scary. In western countries, the prevalence of fatty livers in kids of all weights is 9 to 10 percent. It’s astounding.

"Kids who have NASH, their livers are more susceptible," Smith said. Such patients may later develop life threatening hepatitis cirrhosis. "They will require a liver transplant in their lifetime. It’s one of the highest unmet medical needs," she said. Adults with NASH typically die of other causes before their livers fail.

An inventor on one of Raptor’s patents is a pediatric hepatologist who was treating NASH patients and had one die at age 13. The disease has few symptoms, Smith said, such as upper abdominal pain. NASH occurs even in children who are not overweight. "It appears to be a lifestyle thing," she said, "a television disease" affecting couch potatoes. "The liver is barraged with fatty acids. The continuous insult eventually overcomes the cells," she said, and the inflamed liver cannot recover.

The market for RP103 in pediatric NASH is 500,000 to 1.5 million in the United States, she said. "It’s a large market," she said, but few are diagnosed until the kids are in an advanced stage. Sometimes children are diagnosed when a routine lab test shows massively elevated liver enzymes. A Raptor clinical trial involving 169 patients is underway; patients concluded 12 months of treatment in January and will have a follow up biopsy. Those results are expected by the end of 2015.

Because it’s not an orphan condition (fewer than 200,000), the FDA will likely require further trials, she said. "Before we see the data, it’s impossible to talk about price," she said. "Price needs to be a reflection of the value of that therapy for those patients," she said.

Mitochondrial disease, a genetic flaw
cheap ray ban outlet that impedes cells’ ability to make energy, also may be treated by RP103.

"We’re going after fundamental cellular processes," Smith said of the research. "RP103 offers us a treasure trove of potential biologic actions that we can use to target specific diseases," including disorders involving protein misfolding, fibrosis (excessive fibrous tissue), and mitochondrial stress and dysfunction. "That’s a huge number," she said, "all open to us as potential" applications of RP103, which may slow progression of metabolic decline.

Co founder Starr, her predecessor CEO, worked with the academic research community in early development of RP103. "That was his baby," Smith said. "It was ingenious to recognize the potential broad application." The company owns patents that protect various aspects of RP103 formulation as well as methods of use.Articles Connexes:

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Matthew Fox Learns Fast

Success Secrets Matthew Fox Learns Fast We gave him one day and one goal: Become a race car driver. The front passenger side window glides down, revealing in true movie star fashion a stone faced Fox behind an oversized pair of mirrored Ray Bans. The inside of the car is a vast, inky blackness that contrasts deeply with the sun blasted desert around us.

The actor looks pissed, perhaps because I sort of forgot to pick him up at the hotel earlier that morning. (It was an honest miscommunication.) Or maybe he’s just trying to figure out if I’m the guy he’s supposed to meet. Or perhaps he’s feeling apprehensive, aware that this day could easily end in public humiliation.

Like his character Jack
discount ray bans Shephard, leader of the traumatized, haunted passengers of Oceanic Air flight 815 in ABC’s blockbuster series Lost (which concluded in May 2010), Fox has just crash landed in an alien environment. We’re 80 miles from Hollywood and 2,600 miles from his home on Oahu at Willow Springs International Raceway, an automotive racetrack known for ejecting both timid and overconfident drivers far into the desert sand. Waiting for Fox in the pit is Patrick Long, his instructor for the next 8 hours. A gifted young driver of mind bendingly fast Porsche race cars, Long will raced full time in 2008 as part of Penske Racing’s American Le Mans Series team.

Our goal at Willow is to see if Fox, who starred as Racer X in the 2008 film Speed Racer, can use his famous intellect (he’s a Columbia grad) and physical stamina (think marathon, rain soaked shoots on the set of Lost) to give Racer X a run for his money, despite having never lit up a real racetrack. It’s a challenge any of us would both savor and dread: Given the chance, with your entourage watching, could you master an entirely new skill or sport without falling on your face? How would you pull it off?

Let Matthew Fox be your guide.

Go on to the next page for Matthew Fox’s six step plan for mastering any new skill.

Back at the gate, Fox’s facade
fake ray bans begins to crack. He snaps off the shades and extends his hand. "Good morning," he says. He deflects my regrets for our miscommunication: "Oh, no, don’t worry. I’m really sorry we’re late."

He emerges from the car purposefully, at the pace of someone who’s used to being stared at and who wouldn’t dare risk momentary clumsiness or even excessive exuberance. He moves slowly around today’s ride, a canary yellow Porsche 911. Fox is a lifelong gearhead, and he’s certainly seen his share of high dollar modern sports cars. But he’s not particularly conversant with them. He’s smart enough not to start shooting his mouth off about the car and betray what he may or may not know about cool yellow Porsches. Instead, he studies the rocket and waits patiently to be filled in. It’s a Turbo, with 480 horsepower, 19 inch wheels, huge brakes, and all wheel drive for great traction and handling. Zero to 60 in 3.7 seconds, top speed 190.

He smiles. "All right. I’m excited. Let’s do this thing."

We meet Long at the Streets of Willow, a highly technical 1.8 mile course that packs in more turns than Willow’s 2.5 mile main track. We also meet up with our second ride of the day, a green Porsche 911 GT3 RS. This is the race ready version of the 911 far faster through the turns, thanks to its wider track (the distance between the wheels) and its carbon fiber rear wing. (The wing produces massive downforce, enabling the car to stick to the road like paint.) But Fox will start in the Turbo. He’ll have to earn the GT3.

Step 2: CHANGE YOUR MINDSET

Our first order of business: Scare the bejeezus out of Fox. This will help him shift his thinking more quickly from student to driver.

Long takes Fox out in the Turbo and steadily ratchets up the speed as he briskly hits the basics of track driving. He explains braking points, turn ins (where the car first dives into a turn), and apexes (where it comes closest to the inside of a turn). All three help determine how much speed you’ll be able to carry through a turn and how close you’ll be able to stay to the "line," or the fastest route around any course. "This is a decreasing radius turn, so you want to wait to turn in a little
replica ray ban sunglasses bit later," Long shouts over the jetlike whine of the turbocharger.

"Got it," Fox shoots back.

"For this one, use that cone over there as your signal to start braking, then turn in . . . here. It’s almost like you’re connecting the dots from cone to cone, apex to apex. This next one is a banked corner, so you have lots of grip and can take it pretty fast."

Exiting the banked turn, Fox, who did all his driving scenes in Speed Racer in a studio with the spectacular but wildly unrealistic tracks inserted digitally is stunned by the speed. "Unbelievable!" he shouts.

Long slams the car through the curves, pushing against its road holding limits. Tires squeal. Burnt rubber billows. This is the other half of Fox’s learning curve: the car. Long tells Fox to drive like he’s riding a horse, something that resonates with the actor, who grew up on a Wyoming ranch. "You want to tell the car one thing at a time," Long says. "If you pull a horse’s reins and kick it, it’s going to react awkwardly. In the car, you brake, turn, and then accelerate, but you never do them simultaneously."

The same principle applies to how quickly you do things, he adds. You tense a horse’s reins before pulling them; you don’t just jerk them. Similarly, if you jump on the gas in a car while exiting a turn, the car’s weight will shift to the back tires, reducing the grip of the front tires which are trying to turn and sending you spinning off the course.

After a dozen more laps, each faster than the one before, Long and Fox return to the pit. Fox climbs out slowly, noticeably affected.

"Nauseous?" Long asks.

"A
cheap ray bans little," Fox replies, catching his breath. "I can’t believe how physical that was. I have a totally new respect for you guys."

Step 3: BECOME A STUDENT

Finally, Fox sets out alone in the yellow Turbo. His first recorded lap time: 1:56.44. That’s about 30 seconds slower than the baseline lap time Long set earlier in the day. If that doesn’t sound like much, consider that in a short, 20 lap race, Long would finish 10 minutes ahead of Fox. Of course, it’s early in the day. Fox is still processing Long’s instructions. He’s used to direction repeating specific moves take after take and making subtle adjustments to improve the outcome. So in that respect this is familiar territory.

On a racetrack, every turn requires a unique set of pedal and wheel movements to navigate cleanly. Fox is trying to internalize Long’s advice about transitioning between these movements. "Remember, be patient," Long says when Fox comes in for a quick break. "Lay on the throttle slowly as you’re straightening the car, and always look ahead. When you’re in the middle of one turn, you should be looking to the next apex."

Fox listens intently, nodding briskly and mimicking Long’s hand motions. A few laps later, Fox clocks 1:45.06, then 1:44.25. Long is impressed. "He has a natural sense of what the car’s going to do, and he’s interacting with the vehicle instead of reacting to it. Most important, he has a smile on his face. If he was afraid, he’d have no chance."

Go on to the next page for more on Matthew Fox.

Step 4: FORTIFY YOUR WEAK SPOTS

It’s now midafternoon and Fox is battling creeping fatigue and a touch of motion sickness. Yet he manages to shave his time to 1:40.84 before pulling in for another break. When he hears his time, he high fives his pals. He’s cut 16 seconds from his time in 5 hours. But his biggest challenge, Long tells him, will be trimming the 17th second.Articles Connexes:

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Man lay dead in hospital toilet for 36 hours

According to reports the man, named as Jean Marcel Labb 56, visited the Villeneuve Saint Georges Hospital, in the Val de Marne region to the south of Paris, just before 10am on January 4th to undergo a chest x ray.

When he walked into the hospital he went straight to the disabled toilet where he is believed to have suffered a ruptured aneurysm, causing his sudden death.

His sister Marie Labb described the circumstances around her brother death as terrible and will never know if
discount ray bans he could
fake ray bans have been saved, she told French daily Le Parisien. what disgusts me is that no one seems to have noticed that the door of the toilet was locked for all that time. When he did not return home the family became increasingly worried about his whereabouts. When a family member phoned the hospital just after midday they were told Labb did not have an appointment that day.

want answers from everyone the cleaning staff, who did not do their job, the security officers and the directors of the hospital. It is not normal that this kind of incident can happen, Marie Labb told Europe1 radio.

should never happen again, she said.

The director of the hospital Didier Hoeltgen has denied there were any medical errors surrounding Labb death.

was confusion. People thought the toilet was occupied or out of order. Around 3,000 people come to the hospital each day. We cannot keep a check on all the toilets, Hoeltgen told Le Parisien.

The director has, however, ordered an internal
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PSL teacher negotiations

PORT ST. LUCIE, Fla. Teachers are fighting for a new contract and raise, promising only to do the bare minimum. Now parents are raising concerns about the students missing out. They promised to put in their 8 hours and nothing more. A canceled class trip, a school dance, and play, all end of year traditions moved or canceled due to teacher contract negotiations with the school board.

Maureen Dakin: I think its a shame and I hope it doesnt continue on. I hope there can be some arrangement in the future because really, whether it
replica ray bans be teacher, school board, parent, it really is about the kids.

And the students were upset. They love Epcot.

Victoria Wolfmueller/student: A little, because I was
cheap ray bans looking forward to it all year.

But the teachers did explain why this was happening.

Victoria Wolfmueller/student: Because the teachers needed to stick to their contract and
cheap ray ban outlet that they cant have after school field trips after their hours.

The teachers union promised this tactic would not affect students. But parents say it already is. Some students are upset by a canceled class trip, but others say it makes them support the union’s mission for a raise even more.

Victoria Wolfmueller/student: They do
fake ray bans so much to teach us and we learn so much.

But this is not up to the kids, the district, or the parents, in the end it’s about the school board approving the teachers new contract this summer.

The school did hold the 5th grade dance and reschedule the play, but it was held during school hours, while teachers were paid to be in class. The board votes on the new contract this summer.Articles Connexes:

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Traffic Service Request Official City of Bellevue Website

City Profile ProfileBusiness AssistanceInternational TradeDoing Business with the CitySister CitiesTaxes and Licenses NewsNext Generation BellevueAbout Streams, Lakes
replica ray ban sunglasses and WetlandsDrinking Water ConservationGreen BuildingNatural Lawn and GardenKeeping Waterways CleanCritical AreasSaving
cheap ray bans SalmonGarbage and Recycling ServicesVolunteeringCity HallEmergencies and Extreme Weather PreparednessCity AttorneyCity ClerkCity ManagerCivic Services Services (Permits) FinanceFireHuman ResourcesInformation TechnologyParks Community ServicesPlanning Community PoliceTransportationUtilitiesPlease provide us with some way of reaching you so that we can clarify your request and/or provide you with feedback. This does not
discount ray bans mean that the City will
replica ray bans give out your name. If you believe your life or property will be in danger if your name is disclosed to a requester, check the Do Not Release box below. The City will not disclose your identity in a public records request. If you do not believe your life or property would be in danger if your name is disclosed, check the OK to Release box below. Thank you.Articles Connexes:

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Gill centennial plans under way

FOR MORE than six months, plans have been in the works for the centennial of Manchester’s Gill Stadium, which opened as Textile Field on Sept. 8, 1913.

Those plans are now being finalized by a committee co chaired by George Smith, formerly an alderman and longtime athletics director for the Sweeney American Legion post, and Peter Capano, chief of the city’s Parks, Recreation and Cemetery Division.

Festivities on the original opening day drew capacity crowds totaling around 14,000, according to the Manchester Union, forebear of the New Hampshire Union Leader. About 7,000 spectators filled the stadium for a daytime baseball game between the defending World Series champion Boston Red Sox and an all star team from the local Manufacturing League, the paper reported. Another 7,000 or so came out that night for a soccer game and fireworks display.

Gill will be a festive place again
discount ray bans next Sept. 13, but the festivities won’t include baseball. By the time the 100th anniversary rolls around, Gill be set up for soccer and football, with the pitcher’s mound leveled and bleachers set up in front of left field.

we’ll go with football and soccer, followed by a fireworks show on September 8, Capano said.

Capano had hoped to renew a storied Gill Stadium football rivalry for the occasion, but that’s unlikely to happen. Until they played each other for the last time in 1980, Manchester Central High and Haverhill, Mass., had the fourth oldest high school rivalry in the nation. Capano wanted to see the two schools face each other again.

were trying to get Haverhill to come here next year for the anniversary, but it’s not looking good because of scheduling conflicts, he said. now turned our attention of trying to get Concord to fill that date. some history there, too, Capano noted.

research showed that earlier in the century, Central and Concord both wore red, said Capano. year, both schools agreed to compete for the right to wear that color permanently. The loser would have to choose another color. Concord ended up winning and became the Crimson Tide. became the Little Green.

in the spirit of the centennial, our committee felt a game between Central and Concord would fit perfectly in our plans, Capano said.

Capano said the committee is working on selecting opponents for the soccer game.

Capano said the centennial committee has decided to have every city team that plays at Gill Stadium next year wear a commemorative patch on its uniforms.

were looking into the possibility of scheduling a men’s soccer game between Southern New Hampshire University and St. Anselm College,
discount ray bans he said. received word this week that the Penmen’s 2013 schedule is already set and they’re suppose to host Dowling College on September 8. I’m planning to see if we can move that game to Gill Stadium. If St. Anselm has a home game that day, I’ll ask them if they also want to play it at Gill. We have no problem with scheduling two college soccer games that day. said he’s talked to the city about staging an August or September 5K road race that would start and/or finish at Gill Stadium.

He also said the committee is interested in getting the New Hampshire Fisher Cats to schedule one Eastern League baseball game on Valley Street.

haven’t approached the Fisher Cats yet, but that’s a possibility, he said.

The Fisher Cats played their entire 2004 home schedule at Gill Stadium while their new home, what is now known as Northeast Delta Dental Stadium, was under construction a few blocks away on the banks of the Merrimack River. In their first
cheap ray bans game in New Hampshire, the Fishers faced the Trenton Thunder and their promising second baseman, Robinson Cano.

Whether the Fisher Cats return to Gill or not, there will be plenty of baseball at the stadium next summer. The Manchester Babe Ruth League is planning to host the New England Regional for 13s at Gill in late July and/or early August.

Other possibilities under discussion for the stadium’s centennial year include a boxing event, which New Hampshire Boxing and Wrestling Commissioner Bobby Stephen said he could organize.

While there won’t be a baseball game, committee members hope to have a Red Sox presence for the anniversary.

Red Sox are on our list. We’re focused on bringing retired Red Sox players and even
fake ray bans addressing the idea of inviting owner John Henry, if he has the time, said Capano. still working on it.

People who knew him talk about his love of life, family and friends. He would do almost anything to make another person’s life better.

This past summer, the Manchester Babe Ruth League honored Capistran by naming a scholarship after him. League president Gary Ulbin also had Luke’s initials stitched on the hats of every team in the Ray Lebel and Tom Woodlock leagues.Articles Connexes:

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Hopes mount Greece is close to clinching debt deal

17.55: The FTSE 100 closed up
replica Michael Kors handbags 84.34 points at 7033.33 amid reports Greek leaders are close to striking a deal with creditors that unlocks bailout funds.

The European Commission has denied this but traders seem to think another eurozone fudge to prevent Athens defaulting could well be in the works.

IAG rose as it looks set to forge ahead with its bid for Irish airline Aer Lingus. Imperial Tobacco was another gainer on news it could get the go ahead to buy cigarette brands including Winston and Maverick.

Euro crisis: Greek prime minister Alexis Tsipras, right, and finance minister Yanis Varoufakis, left, leave a meeting at the finance ministry in Athens today

‘London’s FTSE 100 has put in a stellar performance during Wednesday’s session, erasing gains we saw accrued yesterday as hopes rise that a Greek bail out deal is near,’ said Tony Cross of Trustnet Direct.

‘Comments to this effect from Alexis Tsipras have certainly given markets a lift and although the blue chip index is still a little way from testing all time highs, assuming the tailwinds can be maintained then it’s not beyond the realm of possibility that this level could fall, possibly even before the end of the week.

‘The announcement that the conditions for such a deal are being drawn up by creditors raised hopes that we will soon see the final 7.2billion tranche released, paving the way for government pensions and salaries, along with the 1.5billion of IMF payments due in June looking likely to be paid on time.

‘As with almost every stage of this process, a bullish statement from the Greeks has since been denied by the creditors, which on this occasion has fallen to
cheap Michael kors handbags outlet the European Commission vice president Valdis Dombrovskis who has moved to disregard those initial claims.

‘As ever, this leaves everyone no clearer to the actual status of current negotiations and leaves a default as a clear possibility. In any case, it is worth being sceptical when considering such a deal if and when it finally comes, for any ability to meet near term obligations does little to dent the 330billion total debt, which is growing every day.’

On the corporate front, Imperial rose 3 per cent or 109p, to 3393p after US regulators gave approval for Reynolds American to buy smaller rival Lorillard.

The move paves the way for the merged group to sell Imperial around $7billion (4.5billion) worth of brands.

Meanwhile, the Irish government’s decision to sell its 25 per cent stake in Aer
cheap michael kors Lingus to IAG helped lift shares in the BA parent.

The stock rose 3 per cent or 17.5p to 562p after the government and the Irish flag carrier’s board backed its 1.36billion (961million) takeover offer. Last year, Aer Lingus rejected two takeover offers from IAG saying they undervalued the business.

However, budget rival Ryanair, which owns just under a 30 pe cent stake in Aer Lingus, is yet to make a decision on what to do with its holding and could play ‘hard ball’, according to analysts. Ryanair has in recent years made repeated unsuccessful attempts to buy Aer Lingus.

In the FTSE 250, De La Rue, which prints notes for the Bank of England, fell after annual profits fell sharply as it continued
Michael Kors handbags to
Michael Kors discounts face challenging market conditions and price pressures. Its stock slumped 9 per cent or 49.5p to 504p.

Irn Bru maker AG Barr was also lower after it posted a 1.1 per cent fall in sales for the 15 weeks to May 9. Shares fell 8p to 615p.

On currency markets, sterling was pegged back against the greenback after encouraging signs on the US economy including better than expected home sales, durable goods, and consumer confidence data.

The pound fell a cent to just over $1.53 while it also dropped a cent against the euro to a little under 1.41, with the single currency bolstered by hopes of a deal with Greece.

The biggest FTSE 100 Index were CRH up 63p to 1839p, Imperial Tobacco up 109p to 3393p, International Airlines Group up 17.5p to 562p and Ashtead up 33p to 1217p.

The biggest FTSE 100 fallers were Glencore down 3p to 286.8p, Old Mutual down 2p to 229p, Weir Group down 14p to 1988p and SABMiller down 18.5p to 3539p.

17.01:The FTSE 100 closed up 84.34 points at 7033.33. More to come.

15:40: The Footsie has found a new lease of life in late afternoon trading thanks to a strong opening on bourses in the US.

With just under an hour of trading to go in London, the FTSE 100 index was up 73.9 points at 7,035.4 bouncing back from a two week low yesterday and very close to its previous record high reached in April.

In early trade on Wall Street,
replica Michael Kors outlet the Dow Jones industrial average was up 44.77 points, or 0.25 percent, at 18,086.31, the S 500 was up 6.18 points, or 0.29 percent, at 2,110.38 and
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Stock watch: Tiffany Co shares rose after it beat earnings expectations

It comes just a day after US stocks notched their steepest fall in three weeks as the dollar enjoyed its biggest rally in two years.

The bounce back today has largely been driven by a string of good company earnings, namely by jewelry retailer Tiffany which reported better than expected first quarter earnings.

Tobacco giant Reynolds American share price jumped as it received approval from antitrust regulators at the US Federal Trade Commission to acquire Lorillard.

Meanwhile packaged meat company Hormel Foods announced it will acquire privately held organic prepared meat company Applegate Farms for $775million.Articles Connexes:

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Lyndon Johnson was a civil rights hero

Lyndon Johnson said the word "nigger" a lot.

In Senate cloakrooms and staff meetings, Johnson was practically a connoisseur of the word. According to Johnson biographer Robert Caro, Johnson would calibrate his pronunciations by region, using "nigra" with some southern legislators and "negra" with others. Discussing civil rights legislation with men like Mississippi Democrat James Eastland, who committed most of his life to defending white supremacy, he simply call it "the nigger bill."

Then in 1957, Johnson would help
cheap Michael Kors handbags outlet get the "nigger bill" passed, known to most as the Civil Rights Act of 1957. With the 1964 Civil Rights Act and the 1965 Voting Rights Act, the segregationists would go to their graves knowing the cause they given their lives to had been betrayed,Frank Underwood style, by a man they believed to be one of their own.
wholesale Michael Kors handbags outlet When Caro asked segregationist Georgia Democrat Herman Talmadge how he felt when Johnson, signing the Civil Rights Act, said"we shall overcome," Talmadge said "sick."

The Civil Rights Act made it possible for Johnson to smash Jim Crow. government accountable to its black citizens and a true democracy for the first time. Johnson lifted racist immigration restrictions designed to preserve a white majority and by extension white supremacy. He forced FBI Director J. Edgar Hoover, then more concerned with "communists" and civil rights activists, to turn his attention to crushing the Ku Klux Klan. Thoughthe Fair Housing Actnever fulfilled its promise to end residential segregation, it was another part of a massive effort to live up to the ideals America founders only halfheartedly believed in a record surpassed only by Abraham Lincoln.

So it would be tempting, on the 50th anniversary of the Civil Rights Act, as Johnson is being celebrated by no less than four living presidents, to dismiss Johnson racism as mere code switching clever ploy from an uncompromising racial egalitarian whose idealism was matched only by his political ruthlessness.

But that wouldn be true. Johnson was a man of his time, and bore those flaws as surely as he sought to lead the country past them. For two decades in Congress he was a reliable member of the Southern bloc, helping to stonewall civil rights legislation. As Caro recalls, Johnson spent the late 1940s railing against the "hordes of barbaric yellow dwarves" in East Asia. Buying into the stereotype that blacks were afraid of
michael kors handbags outlet snakes (who isn afraid of snakes?) he drive to gas stations with one in his trunk and try to trick black attendants into opening it. Once, Caro writes, the stunt nearly ended with him being beaten with a tire iron.

Nor was it the kind of immature, frat boy racism that Johnson eventually jettisoned. Even as president, Johnson interpersonal relationships with blacks were marred by his prejudice. In Flawed Giant, Johnson biographer Robert Dallek writes that Johnson explained his decision to nominate Thurgood Marshall to the Supreme Court rather than a less famous black judge by saying, "when I appoint a nigger to the bench, I want everybody to know he a nigger."

According to Caro, Robert Parker, Johnson sometime chauffer, described in his memoir Capitol Hill in Black and Whitea moment when Johnson asked Parker whether he prefer to be referred to by his name rather than "boy," "nigger" or "chief." When Parker said he would, Johnson grew angry and said, "As long as you are black, and you’re gonna be black till the day you die, no one’s gonna call you by your goddamn name. So no matter
Michael Kors handbag outlet what you
replica Michael Kors handbags are called, nigger, you just let it roll off your back like water, and you’ll make it. Just pretend you’re a goddamn piece of furniture."

That Johnson may seem hard to square with the public Johnson, the one who devoted his presidency to tearing down the "barriers of hatred and terror" between black and white.

In conservative quarters, Johnson racism and the racist show he would put on for Southern segregationists is presented as proof of the Democratic conspiracy to somehow trap black voters with, to use Mitt Romney terminology, "gifts" handed out through the social safety net. But if government assistance were all it took to earn the permanent loyalty of generations of voters then old white people on Medicare would be staunch Democrats.

So at best, that assessment is short sighted and at worst, it subscribes to the idea that blacks are predisposed to government dependency. That
michael kors handbags outlet doesn just predate
Cheap Michael Kors handbags Johnson, it predates emancipation. As Eric Foner recounts in Reconstruction, the Civil War wasn yet over, but some Union generals believed blacks, having existed as a coerced labor class in America
Michael Kors handbags outlet for more than a century, would nevertheless need to be taught to work "for a living rather than relying upon the government for support."

Perhaps the simple explanation, which Johnson likely understood better than most, was that there is no magic formula through which people can emancipate themselves from prejudice, no finish line that when crossed, awards a person soul with a shining medal of purity in matters of race. All we can offer is a commitment to justice in word and deed, that must be honored but from which we will all occasionally fall short. Maybe when Johnson said "it is not just Negroes but all of us, who must overcome the crippling legacy of bigotry," he really meant all of us, including himself.

Nor should Johnson racism overshadow what he did to push America toward the unfulfilled promise of its founding. They mean they the party that crushed the slave empire of the Confederacy and helped free black Americans from bondage.

But we shouldn forget Johnson racism, either. After Johnson death, Parker would reflect on the Johnson who championed the landmark civil rights bills that formally ended American apartheid, and write, "I loved that Lyndon Johnson." Then he remembered the president who called him a nigger, and he wrote, "I hated that Lyndon Johnson."Articles Connexes:

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Rutland Vermont Hikes

This trail is NOT like Camel’s Hump or Mansfield. It’s a meandering stroll through a meadow like
Michael Kors outlet path with seemingly no elevation gain for what seems like 1 1/2 to 2 miles. When you hit the blue arrow blaze on a rock pointing you to the right and up you’ll start to feel the gain and it
cheap Michael Kors handbags will be steady and straight until you reach the top. You don’t have the luxury of up and down trails to rest your legs and no switchbacks to frustrate you. Just you and a straight line to the top. The trail was relatively dry for having rained a couple of days earlier and if had more recently or had been raining then this might be far more taxing; and slippery. When you reach Cooper Lodge you’ve intersected The Long Trail by a tenth of a mile and water is a short distance away. The lodge obviously sees it’s share of cheaters coming down from the peak via the Gondola and wears the scars to prove it but it was decent and you can’t beat the location. After passing the tent pads you’ve got two tenths to go and you’ll staircase climb on your hands over large rocks almost the entire distance until you reach the over crowded summit. Holiday weekend, foliage season, beautiful (if mid twenties and windy can be beautiful) weather had the peak crowded from K 1′ers.

Overall a great hike on a great day but not as draining as
Michael Kors handbags outlet I would have liked. I only get to Vermont once a year for these trips and I like to remember them as exhausting.

I arrived just after the last of the thunderstorms ended in Rutland that day and was
Michael Kors handbags outlet seriously thinking about postponing till later inthe week. The trail is very flat for close to 2 of the 3.4 miles. The last mile and particularly the last .2 miles are nasty, especially on wet rock, except for a short merge from Bucklin to the LT/AT. The peak spur is included at something near 70
cheap Michael Kors degrees and trekking poles are all
Michael Kors outlet but useless on that portion. The top is a nice wide bare spot but the TV/Radio/Fire towers detract
wholesale Michael Kors handbags outlet from it. I was in the middle of a cloud bank and could barely make out the towers except for a few brief openings. The wind was blowing hard and I was expecting more thunder heads so I made a quick retreat after
cheap Michael Kors handbags outlet pointing an AT hiker to the lift/lodge area below on the ski/north side. Book time is around 5 hours but I made it in 3:45 due to hustling to avoid sunset, bad weather at the top and the ease of ascent/descent over at least 4 of the 6.5 miles. Of all the VT 4000+ footers this was the easiest I have climbed/hiked. The trail is extremely quiet, only saw the one hiker all day. It’s very narrow and damp down at the bottom sections due to lack of foot traffic and fairly flat surface. Stream crossings were simple (unlike some early reports) due to two recent bridges constructed on the trail. The trail head is a bear to find. If you’re heading north from Rutland and you reach Pico you’ve gone too far by 2 right hand turns.

The Bucklin Trail is a blue blazed trail that leads up to the Long Trail and Killington Summit.

It starts off with a nice mellow slight incline for about 45 minutes when the blue blazes make a right and start going uphill. For the next hour you will do some huffing and puffing climbing your way up through the hardwoods that give in to the spruces.

After you reach Cooper”s Cabin you can continue on the blue blazed trail or walk past Cooper”s Cabin and come out on the ski trail and walk up to Killington Peak on the ski trail. Which is alittle easier than the blue blazed trail.Articles Connexes:

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talking about an evolution in the heart of Canberra

Is the changing face of Braddon changing again?

A plaintive piece of graffiti next to the site of the demolished Lonsdale Traders building Bye Bye Braddon suggests to passersby some aren’t pleased with the latest evolution of the inner north suburb.

Is the former car yard strip turned hipster/gourmand enclave becoming something else again? Perhaps something a little more corporate and money ed; less bespoke, more prefab as large new developments replace grungier sites? As higher rents perhaps make it more difficult for the edgier, the creative to survive?

Damien Maher with his wife, Emma, and son, Harry, in Braddon.

But maybe we’re thinking too deeply about it. The developer behind much of the rise and change of Braddon, Nik Bulum, says the ‘Bye Bye Braddon’ graffiti was
fake Michael Kors just a farewell message from departing mechanics when they closed shop.

"Everyone hated that they tore
Michael Kors handbag outlet down Traders because they liked that old warehouse y feel," he said. "But my personal belief is that I think it’s good that it’s developing and changing for the better. And I think there’s the right amount of people to keep this on the right track."

And now, everyone, will get chance to have their say.

Mr Maher’s company Newcast is producing a web series on Braddon called The Lonsdale Street Project to be launched on
cheap Michael Kors handbags outlet Youtube in the next month.

A
discount Michael Kors cleared block of land ready for redevelopment in Lonsdale Street.

Photo: Graham Tidy

Among those contributing to the debate was Mr Bulum, whose family company has on one hand created the grungier success stories such as the Lonsdale Traders and The Hamlet food van site, while also overseeing the rise of large mixed use developments along the street.

Developments Palko and NiBu will rise on the site of the old Lonsdale Traders, featuring apartments, a boutique hotel, laneways and a gallery. Mr Bulum maintains "Lonsdale Street Traders hasn’t died; it’s across the road, just reinvented", referring to the fact some of its pop up tenants have moved into the new Ori building.

Mr Bulum said there was little to love about most of the older buildings in Braddon ("There are heritage listed buidings and they will stay but most are really bad, mid 80s, mall type buildings is that what people want?").

It was the "people and the passion" that had recreated Braddon, he said. "Those buildings were in Braddon for years and no one went there," Mr Bulum said. "It’s the independent businesses opening up that have brought people here."

He also disputed rents
fake Michael Kors were getting out of hand in Braddon, saying there were $350 to $650 per square metre per annum which he maintained was cheaper than the Kingston foreshore.

And Lonsdale Street continues to attract new business, despite talk that rents are on the rise.

Trevor and Che McGee opened their children’s store, Tip You’re In, next to The Hamlet food van outlets just two weeks ago, convinced it was the place to be.

"I haven’t heard anybody say anything bad about Lonsdale Street, I think they all love what’s happening here," Mr McGee said.

"It’s a really, cool vibrant street which is also transforming to an extent. All that talk about being the centre of cool, I don’t think there is a cooler strip than Lonsdale, to be honest."

The McGees have taken a two year sub lease from a previous tenant which occupied one of the older buildings on the strip.

"It’s not cheap but it’s not horrendously expensive," Mr McGee said, of the rent. "I’ve heard some numbers being thrown
cheap Michael kors handbags outlet around in the new buildings of upwards $800
replica Michael Kors outlet
cheap Michael Kors a square metre over the course of a year, which would be very hard for us to deal with."

The McGees will have an option to extend for a further three years at the end of their lease.

"I think we’re a little bit fortunate we’re in one of the older buildings," he said. "I guess as the new buildings are developed and everything is brand, spanking new, the developers obviously have to get their return on that, and that’s where the higher rents are coming in.

"That would be my concern after two years, after we get established what would happen with the rents because you can get priced out of the market. You have to sell a lot of product to pay your rent, let alone yourself and everything else you have to pay."

Meanwhile, Mr Maher, who grew up in Kambah and went on to be a television producer in New York, only to return to to raise a family, says Braddon reminds him of the edgier, village feel of the Lower East Side of New York.

He is convinced Braddon is enjoying its "halcyon days" but maintains it hasn’t peaked. And now is the right time to document it.

"It’s like a teenager, it’s found out it can do all this cool stuff, and filled its boots and I think it’s a good thing to capture that," he said.

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As usual ACTPLA and its big "developers" devoiding this town of character. No wonder so many people think has no soul. New buildings look as cheap as an outback dunny. The pavement is always boring stenciled concrete, no fancy aggregates to at least give it a better look. Everything has a plastic manufactured look these days. No real original ironwork, clay brick or stone masonry. Just good olde’ cheap standard steel girders, concrete besser blocks, reenforced concrete, concrete fading pavers and more grey ugly concrete. The Kingston Foreshore was an epic failure on the design materials front, lets hope Braddon doesn’t follow down the same ugly concrete brutalistic path.Articles Connexes:

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The Benefits And Downsides Of Gluten

It’s not often that a serious medical condition sparks a dieting fad, but such is the case with the gluten free craze. Sufferers of Celiac Disease, an autoimmune digestive ailment, must avoid foods containing gluten but somehow, the diet has caught on with non sufferers who think cutting out gluten will help them eat better or lose weight. It
Michael Kors handbags outlet won’t necessarily do either, yet loads of gluten free products marketed to the general population suggest that it can. Even Domino’s Pizza is on the bandwagon with gluten free pizza crust, although the company’s website cautions that it is not recommended for true Celiac suffers!

Perhaps you’ve considered going gluten free? Before you stop eating breads, pastas, and cereals, let’s look at the facts about gluten, Celiac, gluten intolerance, and gluten sensitivity.

What is Gluten?Gluten is a protein found in wheat that gives elasticity to dough, helping it to rise and keep its shape. Gluten is a combination of gliadin and glutenin, which is joined with starch in various
replica Michael Kors outlet grains. Gliadin is what enables bread to rise properly while glutenin is the major protein in wheat flour, making up 47% of the total protein content.

What Is Celiac Disease?When people with Celiac Disease eat foods or use products containing gluten, their immune system responds by damaging the small intestine. The tiny, fingerlike protrusions lining the small intestine are damaged or destroyed. Called villi, they normally allow nutrients from food to be absorbed into
fake Michael Kors the bloodstream. Without healthy villi, a person becomes malnourished, regardless of the quantity or quality of food eaten.

Recognizing Celiac Disease can be difficult because some of its symptoms mirror those of other diseases. In fact, sometimes Celiac Disease is confused with irritable bowel syndrome, iron deficiency anemia caused by menstrual blood loss, Crohn’s disease, diverticulitis, intestinal infections, and chronic fatigue syndrome. As a result, Celiac Disease is commonly misdiagnosed. According to National Digestive Diseases Clearinghouse, more than 2 million people in the United States are
cheap Michael Kors handbags affected by Celiac disease, or roughly 1 in every 133 people.

More from Fox: The New Treatment For Autoimmune Diseases

Symptoms Of CeliacEarly signs and symptoms of Celiac include: Stomach pain, bloating, gas, decreased appetite, weight loss, intermittent or
Michael Kors handbags constant diarrhea, nausea and/or vomiting, and floating stools that are bloody or fatty in appearance. Long term symptoms include easy bruising, hair loss, missed menstrual periods, fatigue and joint pain, and dermatitis, or itchy skin.

Diagnosing The Disease The results of a blood test can help detect Celiac Disease. If a blood test comes back positive for the appropriate antibodies, an upper endoscopy may be performed to assess possible damage to the small intestine, more specifically the duodenum. If there is a flattening of the villi, those finger like projections that absorb nutrients, the doctor or a registered dietitian will work with the patient to create a gluten free diet. After a few months, the doctor may order another round of blood tests and an endoscopy to evaluate the body’s response. Genetic testing is also helpful for relatives of those with Celiac Disease, as the disease is hereditary and common among first degree relatives.

The Longterm Damage Of CeliacAccording to the American Celiac Disease Alliance, eating gluten can cause those with Celiac Disease to be malnourished. This is because the body cannot absorb vitamins and minerals from food, and instead excretes them in the stool. This can cause weight loss
cheap Michael Kors outlet and vitamin deficiencies, which if severe enough can lead to stunted growth, neurological problems, and low bone density. Calcium and vitamin D are lost in
Michael Kors outlet the stool as well, which can lead to rickets in children (a type of kidney stone), as well as osteomalacia (softening of bones), osteopenia, and osteoporosis. Cancer, especially gastrointestinal cancer, has also been reported to occur in cases of longstanding untreated celiac disease.

More from Fox: Endoscopy Overused In Heartburn Patients

Celiac’s Dietary RestrictionsSufferers of Celiac Disease cannot eat foods made with all purpose flour, bleached flour, bran, couscous, wheat bran, or wheat starch, among others. Under new labeling laws, any foods containing wheat must be identified in the ingredients section on the food label. Celiac suffers must also avoid rye
Michael kors handbags outlet and barley, the latter of which is often used as malt flavoring. Oats can be tricky: Pure, uncontaminated oats consumed in moderation (up to 1/2 cup of dry oats daily) may be tolerated by some, but not all, celiacs. Gluten free alternatives include rice, corn (maize), soy, potato, tapioca, beans, quinoa, and nut flours. The Celiac Disease Foundation is a good resource for information about gluten free foods.

Gluten Intolerance And Gluten SensitivitySome people suffer from gluten intolerance, which is different from Celiac in that it is not an immune mediated response. The symptoms of gluten intolerance appear after eating wheat or other foods containing gluten, which can cause abdominal cramping, bloating, diarrhea, and flatulence. Researchers are still investigating whether gluten intolerance over a long period causes permanent intestinal damage.

More commonplace is gluten sensitivity, which affects approximately 18 million people in the United States and is essentially a less severe form of gluten intolerance. The gastrointestinal symptoms are similar to those that affect individuals with Celiac Disease, but gluten sensitivity does not cause damage to the intestinal lining.

Should You Go Gluten Free?Of course, eating gluten free makes sense for anyone with Celiac Disease or a significant sensitivity to gluten. But for the majority of us who are not bothered by gluten, are there real benefits to the diet overhaul? Not really, although some people report feeling better after reducing their intake of products with gluten. But take note: A food billed as "gluten free" isn’t necessarily healthier. Gluten free products can be high in calories, fat, and carbohydrates, and some people who go gluten free actually gain weight. That said, so long as you continue to eat a balanced diet, cutting gluten probably won’t cause any harm.Articles Connexes:

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Neon Rider star Winston Rekert dies of cancer

Actor Winston Rekert who delighted Vancouver audiences on stage at the Arts Club Theatre and global audiences as the star of Neon Rider and
fake Michael kors handbags outlet Adderly died early Friday of cancer at the age of 63.

Born and raised in
replica Michael Kors outlet Vancouver, Rekert got his start at the Arts Club with a single line, "Did anyone order a taxi?" in
cheap Michael Kors outlet a production of Hot L Baltimore. Rekert took that taxi to stardom, soon becoming one of the country’s best known actors.

"Memories of his work will live on," Arts Club artistic managing director Bill Millerd told The Sun. "Winston was a ‘natural’ actor who followed his instincts.

"He spoke from his heart and was always honest on stage. He was gruff and could be menacing, but if a moment didn’t feel right, he couldn’t do it. His work with Susan Wright in a couple of shows in the early days at Seymour Street and with Janet Wright in The Sea Horse speaks to his singular talent."

Beyond his talent Rekert was also known for his sense of humour.

"Winston did have a terrific sense of humour," recalls Millerd. "After the last performance of The Sea Horse with Janet Wright at the Granville Island Stage they took their dressing room chairs and launched them into False Creek in front of the lounge."

Blessed with leading man looks, Rekert became a national phenomenon when he starred as the title character in the acclaimed coroner series, Adderly which ran on CBS between 1986 and 1989.

When Adderly was
cheap Michael Kors handbags outlet cancelled he and his childhood friend Danny Virtue began pitching a TV movie called Dude that was described as "Fame goes Outward Bound." Dude
wholesale Michael Kors handbags outlet became Neon Rider which ran from 1990 to 1995 with Rekert starring as Michael Terry, a psychologist who takes troubled teens out of the big city (Vancouver) and tries to sort out their problems back at the ranch (in Mission). Through the show he became involved with a variety of youth groups and was named the national spokesman for Youth at Risk. Performers to recognize his outstanding body of work.

Rekert began acting at age 12 in an amateur production of Amahl and the Night Visitors. After high school, Rekert spent a year working in a logging camp, then took a year off to try his hand at acting and soon found himself on stage at the Arts Club and onscreen on The Beachcombers.

In the 1970s, Rekert made the pilgrimage to Toronto landing leading roles in American and Canadian productions, and collecting a Gemini Award for Best Performance by a Lead Actor in a Continuing Dramatic Role for the TV Series Adderly in 1987. He collected a second Gemini for Best Performance by an Actor in a Guest Role in a Dramatic Series for TV’s Blue Murder in 2003. including Cold Squad, Supernatural, Stargate SG 1 and Battlestar Galactica. His movie career included roles in films such as Agnes of God.

As news spread that Rekert had succumbed to cancer, the Facebook pages of Vancouver actors were covered
michael kors handbags outlet with tributes, many thanking him for his generosity or for providing them with their first big break.

Actress and director Colleen Winton wrote, "Aside from his long list of credits as an actor, he did such a service to this community with the creation of the series Neon Rider. A real treasure. burns through budget for fighting forest firesWarning for hikers, motorists as wildfires burn near Pemberton, LyttonPublic warned to stay away from Elaho Valley near Pemberton as wildfire burnsElaho wildfire spreading near PembertonHeavy smoke from Elaho fire drifts into Pemberton, Squamish valleySign up for breaking news alerts and newsletters

Developer demands local buyer for $18 million downtown Vancouver penthouseMore than 150 metres above sea level, way up here in this rarefied air, the view goes on forever, past the rival Shangri La Hotel tower and the
Michael Kors handbag outlet freighters in English Bay, beyond the Strait of Georgia and Vancouver Island mountains. Watching the sunset from this vantage point is like meeting with God.

more 4 hours agoVideo: Why are homes so costly?Is there more to this story? We’d like to hear from you40% of Vancouverites feel priced out of townPete McMartin: Australia has real estate data about offshore investment; why don’t we?Experts calling for more data on foreign investment in Canadian real estateFreer flow of Chinese currency could boost sales, Vancouver realtor saysRobertson says federal politicians must respond to housing crisisFlipping Vancouver homes proves profitablePart 3 of 3: Ritzy Richmond neighbourhood where many are ‘poor’China appears ready to allow more of its currency to move overseasNanaimo RCMP investigating possible hate crime targetting Asian realtors’ signsArticles Connexes:

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